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Regarding chronic chagasic myocarditis, myocardial fibrosis is probably implicated in the genesis of malignant ventricular tachyarrhythmias (ventricular tachycardia and ventricular fibrillation), major causes of sudden death among patients with chronic Chagas' heart disease. myocarditis: Definition Myocarditis is an inflammatory disease of the heart muscle (myocardium) that can result from a variety of causes. While most cases are produced by a viral infection, an inflammation of the heart muscle may also be instigated by toxins, drugs, and hypersensitive immune reactions. Myocarditis is a rare but serious Myocardial fibrosis refers to an increase in collagen volume within the extracellular interstitium 1-3.
In chronic myocarditis, viremia is often absent and myocardial fibrosis and dilated cardiomyopathy (DCM) resulting in heart failure can occur. The role of cardiac MRI in chronic myocarditis is not yet well understood. MRI is a sensitive tool detecting myocardial fibrosis on late images after application of paramagnetic contrast agents. In contrast, chronic inflammatory cardiomyopathy indicates myocardial inflammation with established dilated cardiomyopathy or hypokinetic nondilated phenotype, which in the advanced stages evolves into fibrosis without detectable inflammation. The pattern of myocardial fibrosis in chronic Chagas' heart disease probably reflects the pathogenic mechanisms involved.
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The diagnosis of myocarditis has changed due to the introduction of cardiac magnetic resonance imaging. Regarding chronic chagasic myocarditis, myocardial fibrosis is probably implicated in the genesis of malignant ventricular tachyarrhythmias (ventricular tachycardia and ventricular fibrillation), major causes of sudden death among patients with chronic Chagas' heart disease. Infectious virus is not present during the development of chronic myocarditis, and is not reactivated by IFN-γ deficiency.
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There is controversy surrounding theories concerning the pathogenesis of chronic chagasic Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion results Chronic myocarditis and fibrosis is increased in IFN-γ-deficient mice. Mice deficient in IL-12Rβ1 (IL12R−/−) or IFN-γ (IFNg−/−) were compared to wild-type BALB/c control mice for the level of myocarditis and fibrosis in the heart 35 days after CB3 infection. Objective: To explore the effect of microRNA-21 (miR-21) on myocardial fibrosis in mice with chronic viral myocarditis (CVMC) and related mechanisms.Methods: Forty 4-week-old Balb/c male mice were randomly divided into 4 groups (n=10 each): phosphate buffer saline (PBS) group, CVMC group, CVMC+miR-21 inhibitor group, CVMC+isotype control group. Regarding chronic chagasic myocarditis, myocardial fibrosis is probably implicated in the genesis of malignant ventricular tachyarrhythmias (ventricular tachycardia and ventricular fibrillation), major causes of sudden death among patients with chronic Chagas' heart disease.
Idiopathic pulmonary fibrosis
Villkor: Acute Myocarditis; Dilated Cardiomyopathies; Hypertrophic Villkor: Chronic Obstructive Pulmonary Disease (COPD) Villkor: Cystic Fibrosis.
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T2 - Mechanisms of Cardiac Injury, Inflammation, and Fibrosis.
Macrophage influx and galectin 3 production have been suggested as major players driving acute inflammation and chronic fibrosis in many diseases.
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Inflammatoriska systemsjukdomar Flashcards Quizlet
402 Other specified pneumoconiosis and pulmonary fibrosis of occupational origin. 82, EA31, Cystisk fibros, Cystic fibrosis, E84.0→E84.9. 83, FA01, IVA delirium, ICU 139, IA19, Myokardit, Myocarditis, I40.0→I41.8.